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Circadian characteristics of serum calcium, magnesium and eight trace elements and of their metallo-moieties in urine of healthy middle-aged men.

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Citations

0

References

2009

Year

Eugene L. Kanabrocki, Robert B. Sothern, M D Ryan, Steven E. Kahn, G J Augustine, C L Johnson, S. Foley, A Gathing, Gerard Eastman, Nicholas Friedman,
PubMed

Abstract

Significant circadian variations were found in levels of nearly every element that was measured in blood and urine of 11 healthy men, but with highest and lowest levels occurring at different times. This suggests not only that urine concentrations need to be adjusted for collection time interval and urine volume, but that different biological limits at different times of the 24h day should be applied for serum and urinary monitoring of trace elements. We also found that the non-dialyzable segments of these elements in urine represent metallo-moieties composed of proteinacious matter greater than 12,000-14,000 Daltons. Further studies would be of interest to reveal time specificity for metabolic functions associated with any of these trace elements.