Inability of low thymine-requiring mutants of Escherichia coli lacking phosphodeoxyribomutase to be induced for deoxythymidine phosphorylase and deoxyriboaldolase

Abstract

activity, establishing abiochemical basis forthelowrequirement. Alsopresented weredataindicating that bothdeoxythymidine phosphorylase anddeoxyriboaldolase wereinduced coordinately when E.coli wasgrownondeoxythymidine. We suggested that deoxyribose 5-phosphate (dR-5-P) was moredirectly involved withthese inductions than wasdeoxyribose 1-phosphate (dR-1-P), thecompound implicated byW.E.Razzell andP.Casshyap TABLE1.Metabolism ofdeoxythymidine (dThd) bygrowing cultures ofEscherichia colia