PubMed · 1991 · 81 citations · 10 references
Open access
PharmacyPharmacokineticsPharmacologyBioavailabilityClinical PharmacologyDrug ClearanceComparative PharmacokineticsDrug DispositionDrug Half-lifeHalf-life EstimationComparative Intravenous PharmacokineticsCyclosporine PharmacokineticsPharmacokinetic Study Design
F K 506 is currently used as the primary immunosup- pressant in.over 800 organ tra~splant pati~nts at ~e University of Pittsburgh.FK 506 IS a macrolide and IS chemically very different from any other immunosuppressive drug used currently in transplant patients.Howe .. cr, FK 506 is very similar to cyclosporine (Cy A) in a numt-er
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A highly sensitive method to assay FK-506 levels in plasma.
Kyoichi Tamura, Minoru Kobayashi, Kazuhiko Hashimoto et al. · PubMed · 1987 · 148 citations
Pharmacokinetics of FK 506: preclinical and clinical studies.
Raman Venkataramanan, A Jain, Evan M. Cadoff et al. · PubMed · 1990 · 123 citations · Full text