Comparison of two non-absorbable antibiotics for treatment of bacterial enteritis in children.

Abstract

Thirty-one children with bacterial diarrhoea were administered an oral suspension of rifaximin (14 children, mean age: 4.3 yrs; dosage: 5 ml, equal to 100 mg, x 4/day for 3 days on average) or of neomycin + bacitracin (17 children, mean age: 3.6 yrs; dosage: 5 ml x 4/ day for 4 days on average). Etiologic agents were: minor Salmonella spp in 9 and 7 cases respectively; enteropathogenic E. coli in 5 and 10 cases. Rifaximin yielded bacteriological cure in 12/14 children; the reference drug in 13/17. With both antibiotics, stool number/day fell, after one day, from 6 on average, to normality (2-3 stools); within two days stool consistency and characteristics shifted to normal. Symptomatology was quickly eliminated in all of the cured children. Both treatments showed excellent systemic tolerability; rifaximin was completely tolerated also locally, while two cases of stomach ache were reported with the reference drug.