In vitro and in vivo Antitumor Activity of the Fruit Body of Phellinus linteus

Abstract

This study was undertaken to investigate immunochemotherapeutic activity against tumor growth and cytotoxic activity against tumor cell lines. Phellinus linteus (PL), which was artificially cultured in Morus alba, prolonged significantly the survival rate of mice intraperitoneally implanted with sarcoma 180 and inhibited solid tumor growth on mice subcutaneously implanted with sarcoma 180. The acetone precipitate of water extract of PL was better than its water extract. However, PL showed little cytotoxic activity against tumor cell lines.