Effect of Initial Empiric Antibiotic Therapy Combined with Control of the Infection Focus on the Prognosis of Patients with Secondary Peritonitis

Abstract

Inappropriate initial empiric antibiotic therapy was associated with higher rates of therapeutic failure, surgical site infection, re-operation, and death. Classification of therapeutic failure into four categories according to the appropriateness of empiric antibiotic therapy and the success of infection control provided excellent discrimination of morbidity and death.