PubMed · 1977 · 12 citations · 0 references
MedicineBiochemistryOncologyBreast OncologyCarcinogenesisNeoplasiaCarcinogenicity AssessmentChemical CarcinogenesisMalignant NeoplasmsMammary TumorsOxidative Stress In CarcinogenesisReactive Oxygen SpeciesEnzyme ConcentrationMechanisms Of CarcinogenicityMechanisms Of Chemical CarcinogenesisOxidative Protein DamageOxidative Stress In CancerRedox Metabolism In CancerSuperoxide Dismutase Function
In female Sprague Dawley rats, the tissue protein is homogeneously distributed and significantly increased in 7,12-dimethylbenz[a]anthracene-initiated mammary carcinoma. At the centre and margin of the carcinoma, the concentration of superoxide dismutase is 54 +/- 10 and 117 +/- 38 microgram/g, respectively, while in the tumour as a whole it is 104 +/- 32 microgram/g. The latter value is not significantly different from 113 +/- 35 microgram/g, the enzyme concentration in mammary tissue from lactating rats. Exposure of the tumour-bearing rats to hyperoxia does not increase the tumour protein but raises the enzyme concentration at the centre and margin of the carcinoma to 162 +/- 73 and 286 +/- 103 microgram/g, respectively.