PubMed · 2014 · 18 citations · 0 references
MedicineDermatologyEndocrinologyDermatopathologyEndocrine PharmacotherapyReproductive EndocrinologyDrug-induced Skin ReactionsMelanocytic LesionsMelasma ManagementPigmentary DisordersEthnic Variations In MelasmaFinasteride TherapyHistopathology Of MelasmaHormonal Influences In MelasmaMelasma TreatmentPathogenesis Of MelasmaProgesterone Immunomodulation
Melasma is an acquired hypermelanosis that typically affects sun-exposed areas on the face and presents as symmetric brownish macules and patches. It is most commonly reported in women and thought to be related to the effects of estrogen and progesterone on melanocytes. Since the advent of finasteride 1mg daily tablets for the treatment of androgenic alopecia, we have noticed an increase in the number of men presenting with melasma. Here we present one of those cases. We hypothesize this could be related to the effects of finasteride on estrogen and progesterone concentrations in the skin.