Clinical Pharmacology & Therapeutics · 1977 · 33 citations · 0 references
PharmacyPharmacokineticsPharmacologyDrug ClearanceRenal PharmacokineticsRenal PharmacotherapyDrug DispositionPharmacokinetics In Renal ImpairmentPharmacokinetics Of AntimicrobialsRenal ClearanceRenal Drug ClearanceSolute ClearanceBolus Intravenous DosingGlomerular Filtration Of DrugsIntravenous Bolus InjectionInulin ClearancePharmacokinetics Of Antimicrobial AgentsRenal Blood ClearanceRenal Clearance EffectsRenal Function Effects On Clearance
Furosemide was shown to decrease inulin clearance in 20 of 27 normal subjects. The depression in inulin clearance occurred in both water-loaded and non-water-loaded subjects. The renal clearance of practolol, but not digoxin, was reduced when furosemide was given. The average total plasma clearances of gentamicin and of cephaloridine over a 6-hr period were decreased after furosemide. The reduced clearances of the antibiotics were associated with higher plasma levels, the increase in antibiotic concentration being as much as 100% at 1 hr after an intravenous bolus injection.