In vitro evaluation of the permeation of cytotoxic drugs through reconstructed human epidermis and oral epithelium.

Abstract

Although the skin epidermis with keratinised stratum corneum provided relatively good protection, uptake (of at least some investigated drugs) via both types of tissue should not be underestimated. Our results provide basic experimental data on the skin and oral epithelia permeation for further modelling of exposure and health risk assessment.