The measured pharmacokinetic and pharmacodynamic parameters for both 5 and 10 mg day(-1) donepezil administered in the evening are in good agreement with previous results obtained with morning administration, indicating no time of dosing effect.
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Samantha Rogers, Lawrence Friedhoff · European Neuropsychopharmacology · 1998 · 293 citations
Interim Analysis, Alzheimer's Disease, Long-term Efficacy +8
Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses
Rogers, Cooper, Sukovaty et al. · British Journal of Clinical Pharmacology · 1998 · 168 citations · Full text