Concepedia

Publication | Closed Access

Molecular mechanisms of drug resistance in Mycobacterium tuberculosis clinical isolates.

12

Citations

0

References

1999

Year

Xuanyan Wu, J Zhang, Y Zhuang, X Zhang, Guomei Li, Xiaojun He
PubMed

Abstract

Most drug resistance in M. tuberculosis was due to simple mutations occurring in chromosomally encoded genes. Alterations in rpoB, rpsL and katG gene may be the important mechanism of M. tuberculosis resistance to RFP, SM, and INH. PCR, PCR-SSCP, PCR-NS, and PCR-RFLP are going to become the simple, rapid and reliable diagnostic tests for drug resistance in M. tuberculosis.