A controlled clinical trial to evaluate the safety and whitening efficacy of a 9.5% hydrogen peroxide high-adhesion whitening strip in a teen population.

Abstract

36 subjects completed the study. At each post-baseline visit, both of the treatment groups had statistically significant (P < 0.02) mean color improvement from baseline for b*, L* and a*. The 9.5% hydrogen peroxide strips group provided statistically greater reduction in yellowness (deltab*) relative to the 6.5% hydrogen peroxide strips group for each visit of in the maxillary arch (P < 0.02) and for Day 8 and Day 22 in the mandibular arch (P < 0.02). In addition, the 9.5% hydrogen peroxide high-adhesion strip group provided statistically greater improvement in lightness (deltaL*) relative to the 6.5% hydrogen peroxide strip group for each visit in the maxillary arch (P < or = 0.007) and for the final visit in the mandibular arch (P = 0.002). 18 subjects (62%) in the 9.5% hydrogen peroxide high-adhesion strip group reported adverse events compared to 8 subjects (53%) in the 6.5% hydrogen peroxide polyethylene strip group. Minor and transient tooth sensitivity and oral irritation were the most common adverse events.