PubMed · 1985 · 14 citations · 0 references
PharmacyPharmacologyPharmacotherapyDrug ClearancePharmacokinetic VariabilityRenal PharmacokineticsRenal ClearanceRenal Drug ClearanceRenal Drug DistributionRenal Function TestsRenal ImpairmentRenal PharmacologyIndividual Response VariabilityLithium Clearance MeasurementLithium Dosage AdjustmentLithium Dose-response RelationshipLithium PharmacokineticsLithium PharmacologyLithium TreatmentSerum Lithium Concentration
The effect of steady state therapeutic theophylline serum levels on lithium renal clearance was investigated. Group mean lithium renal clearances and serum lithium levels varied in predicted fashion. Individual variability in these parameters was significant. Clinical implications are considered and management suggestions made.