Excitatory amino acid receptors : design of agonists and antagonists

Abstract

Excitatory amino acids, excitotoxicity and neurodegenerative disorders excitatory amino acid receptors - multiplicity and ligand specificity of receptor subtypes isolation and structural characterization of excitatory amino acid receptors electrophysiological techniques for the study of excitatory amino acids in mammalian neurones in slice preparations receptor autoradiography of excitatory amino acid receptors - basic and clinical aspects NMDA receptors - heterogeneity and agonism sulphur - containing excitatory amino acids competitive NMDA receptor antagonists ligands for NMDA receptor modulatory sites AMPA receptor agonists - structural, conformational and stereochemical aspects quinoxalinediones as AMPA receptor antagonists - mechanism and structure activity studies kainic acid receptor agonists polyamine toxins as excitatory amino acid receptor ligands L-AP4 receptor ligands the quisqualate metabotropic receptor coupled to phospholipase C (Qp) therapeutic opportunities in modulators of excitatory amino acid mediated neurotransmission.