PubMed · 2008 · 51 citations · 12 references
DentistryOral BiologyDental MaterialsDental CementsDevelopmental Dental AnomaliesLuting CementsTooth DevelopmentLuting Cement ApplicationsMsx1 VariantsPermanent Luting CementsSolubilitySorptionWater Sorption And SolubilityWater Vapor Sorption
OBJECTIVE: To determine dental agenesis prevalence in Sayada, Tunisia, a town from where many patients attend the Pediatric Department of Monastir University Dental School for such abnormalities, and to analyze its mode of inheritance. METHOD AND MATERIALS: A total of 262 schoolchildren in permanent dentition (134 females and 128 males) aged 12 to 18 years (mean, 14.1 +/- 1.2 years) were examined to detect dental agenesis. In the case of a missing permanent tooth, a panoramic radiograph was taken to confirm diagnosis. A family survey questionnaire was completed for each case of multiple agenesis (at least 4 teeth missing). RESULTS: Findings revealed a dental agenesis prevalence of 13.3%. Altogether, 62 teeth were missing. No case of syndromal agenesis was detected; however, 12 children presented multiple agenesis (34.3%). The family survey was completed for only 9 of these subjects. CONCLUSION: Literature review showed a lower dental agenesis prevalence (3% to 7%) than did the present study. In the present study, females were more affected by this abnormality than males (16.4% and 10.3%, respectively). With the exception of third molars, the tooth most often missing was the mandibular second premolar (30.6%), followed by the maxillary second premolar (17.7%); hypodontia seemed to be symmetrical. Family surveys revealed a high rate of consanguinity in Sayada. Pedigree analysis of 9 families showed that dental agenesis was probably related to an autosomal dominant inheritance.
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Hypodontia in the permanent dentition.
K Hunstadbråten · PubMed · 1973 · 230 citations
<i>MSX1, PAX9</i> , and <i>TGFA</i> Contribute to Tooth Agenesis in Humans
Alexandre R. Vieira, R. Meira, Adriana Modesto et al. · Journal of Dental Research · 2004 · 173 citations
Novel Mutation of the Initiation Codon of <i>PAX9</i> Causes Oligodontia
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A novel <i>MSX1</i> mutation in hypodontia
S De Muynck, Els Schollen, Gert Matthijs et al. · American Journal of Medical Genetics Part A · 2004 · 91 citations