Prodrugs of Peptides. 13. Stabilization of Peptide Amides Against α-Chymotrypsin by the Prodrug Approach

Penetration and enzymatic barriers to peptide and protein absorption

Vincent H.L. Lee, Akira Yamamoto · Advanced Drug Delivery Reviews · 1989 · 408 citations

Pharmacy, Biochemistry, Pharmacokinetics +12

Use of the specificity constant of .alpha.-chymotrypsin

Frederick E. Brot, Myron L. Bender · Journal of the American Chemical Society · 1969 · 86 citations

Natural Sciences, Chemistry, Analytical Chemistry +6

Prodrugs of Peptides. 6. Bioreversible Derivatives of Thyrotropin-Releasing Hormone (TRH) with Increased Lipophilicity and Resistance to Cleavage by the TRH-Specific Serum Enzyme

Judi Møss · Pharmaceutical Research · 1990 · 77 citations

Pharmacy, Biochemistry, Pharmacology +16

(C) Means to enhance penetration

Advanced Drug Delivery Reviews · 1992 · 68 citations

Computing, Computer Science, Computer Security +5

Prodrugs as Drug Delivery Systems IV: N-mannich bases as Potential Novel Prodrugs for Amides, Ureides, Amines, and Other NH-acidic Compounds

Marianne Johansen · Journal of Pharmaceutical Sciences · 1980 · 62 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +8