Concepedia

A possible mechanism of impaired NK cytotoxicity in cancer patients: Down-regulation of DAP10 by TGF-β1

June Chul Lee, Kyung‐Mi Lee, Yong‐Oon Ahn, Beomseok Suh, Dae Seog Heo

Tumori · 2011 · 18 citations · 23 references

DOI

Concepts

Abstract

Aims and backgroundElevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. However, the molecular mechanism of immunosuppression by TGF-β1 is n...

References

23

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

Veronika Groh, Jennifer D. Wu, Cassian Yee et al. · Nature · 2002 · 1.6K citations

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Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

Tamotsu Yoshimori, Akira Yamamoto, Yoshinori Moriyama et al. · Journal of Biological Chemistry · 1991 · 1.4K citations · Full text

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Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

Veronika Groh, Rebecca L. Rhinehart, Julie Randolph‐Habecker et al. · Nature Immunology · 2001 · 953 citations

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Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells

Roberta Castriconi, Claudia Cantoni, Mariella Della Chiesa et al. · Proceedings of the National Academy of Sciences · 2003 · 697 citations · Full text

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Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients

June-Chul Lee, Kyung‐Mi Lee, Dong‐Wan Kim et al. · The Journal of Immunology · 2004 · 539 citations · Full text

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