STUDIES ON TWO SPORADIC CRETINOUS BROTHERS WITH GOITER, TOGETHER WITH SOME REMARKS ON THE RELATION OF HYPERPLASIA TO NEOPLASIA

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Article1 October 1946STUDIES ON TWO SPORADIC CRETINOUS BROTHERS WITH GOITER, TOGETHER WITH SOME REMARKS ON THE RELATION OF HYPERPLASIA TO NEOPLASIAJ. LERMAN, M.D., H. W. JONES, M.D., E. CALKINS, M.D.J. LERMAN, M.D.Search for more papers by this author, H. W. JONES, M.D.Search for more papers by this author, E. CALKINS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-4-677 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur interest in the pathology and pathological physiology of cretinous goiters was stimulated by the discovery and study of two cretinous brothers, both possessing goiters. The results of this study, plus additional observations on two other cretinous subjects with goiter, on patients treated with thiouracil and on experimental animals, have been the basis of speculation regarding the rôle of hyperplasia in the genesis of neoplasia. Since studies of the type made on the two cretinous brothers are instructive, the results are presented below in detail, together with brief clinical histories.CASE REPORTSCase 1. R. W., a 19 year old...Bibliography1. HAMILTONSOLEYREILLYEICHORN JGMHWAKB: Radioactive iodine studies in childhood hypothyroidism, Am. Jr. Dis. Child., 1943, lxvi, 495. Google Scholar2. RAWSONTANNHEIMERPEACOCK RWJFW: The uptake of radioactive iodine by the thyroids of rats made goiterous by potassium thiocyanate and by thiouracil, Endocrinology, 1944, xxxiv, 245. CrossrefGoogle Scholar3. MARINELENHART DCH: The pathological anatomy of the human thyroid gland, Arch. Int. Med., 1911, vii, 506. CrossrefGoogle Scholar4. HELLWIG CA: Thyroid adenoma in experimental animals, Am. Jr. Cancer, 1935, xxiii, 550. CrossrefGoogle Scholar5. BIELSCHOWSKY F: Tumours of the thyroid produced by 2-acetylaminofluorene and allylthiourea, Brit. Jr. Exper. Path., 1944, xxv, 90. Google Scholar6. Editorial: Thiourea and experimental carcinogenesis in the thyroid, Jr. Am. Med. Assoc., 1945, cxxvii, 278. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication February 5, 1946.From the Thyroid Clinic of the Massachusetts General Hospital, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE HYPOTHYROID STATESDyshormonogenetic goiter: A clinicopathologic study of 56 casesDyshormonogenetic goiter: A morphological and immunohistochemical studyThe diagnosis of malignancy in dyshormonogenetic goitreHazards in the diagnosis and management of certain thyroid nodules in childrenThe pathology of dyshormonogenetic goitreDyshormonogenesis and Carcinoma of the Thyroid GlandGoitrous CretinismThe Treatment of HypothyroidismPhysiology of the Thyroid GlandTherapeutic concepts relating to hypothyroidism in childhoodFamilial Deafness and Goitre in Persons with a Low Serum Level of Protein-Bound Iodine: Preliminary ReportSporadic cretinism with goiter occurring in identical twinsGoitrous HypothyroidismInfantile HypothyroidismThyroid Disorders in ChildhoodSPORADIC NON-ENDEMIC GOITROUS CRETINISMSPORADIC NON-ENDEMIC GOITROUS CRETINISMThe role of congenital anomalies in the etiology of chronic diseasesThe Nontoxic Nodular Hyperplastic GoiterClinical EndocrinologyNon-endemic Goitrous CretinismThe Value of a Single Injection of Thyrotropin in the Diagnosis of Obscure HypothyroidismSURGICAL TREATMENT OF VARICOSE VEINSTHYROID FUNCTION IN CRETINSFAMILIAL CRETINISMRADIOACTIVE-IODINE STUDIES IN NON-ENDEMIC GOITROUS CRETINISMCase 38331 1 October 1946Volume 25, Issue 4Page: 677-701KeywordsHospitalsObservational studiesThyroid ePublished: 1 December 2008 Issue Published: 1 October 1946 PDF downloadLoading ...