Glyceryl trinitrate treatment of chronic fissure in ano: one year's experience with 0.5% GTN paste.

Abstract

The use of 0.5% GTN induces rapid healing of chronic anal fissures with a 73% healing rate in this study. Successful treatment may come at the expense of a high incidence of headaches and a lower compliance than found in studies involving a lower concentration of GTN. A balance is required between fissure healing and headache intolerance.