SUCCESSFUL ORTHOTOPIC TRANSPLANTATION OF LIVER HOMOGRAFTS AFTER EIGHT TO TWENTY-FIVE HOURS PRESERVATION.

Abstract

DOG LIVER HOMOGRAFTS were preserved with varying techniques and tested by orthotopic homotransplantation to unrelated mongrel dog recipients.T h e latter were treated with a~athioprine, antilymphocyte globulin, and a short coursc of prednisone.There were 6 groups of experiments:Group I-Controls.Twelve homografts were removed from cooled donors,-infused through the portal vein with chilled electrolyte solution, and transplanted within a n hour.Only 1 recipient died in less than a week.Imposing an arbitrary limit of 70 days survival for individual animals, the mean survival was 38.7 * 29(SD) days.Evidence of acute ischemic injury of these organs was minimal.