PubMed · 1978 · 63 citations · 3 references
PharmacyNeurologyPharmacologyNeuropharmacologyNeurotoxicologyPharmaceutical ToxicologyCentral Nervous System ToxicityClinical NeurotoxicologyDrug-induced NeurotoxicityNeurotoxic MechanismsNeurotoxicity AssessmentPeripheral Nervous System ToxicityAnticonvulsant NeurotoxicityBrain ToxicityCentral Nervous System Drug ExposureDrug-induced Peripheral NeuropathyHuman Clinical NeurotoxicityNeurotoxicity Of DrugsPeripheral Neuropathy PharmacotherapyTotal Dose
Misonidazole has been given to a total of 87 patients. Neurotoxicity has occurred--convulsions with the higher doses and peripheral neuropathy with the lowern ones. The data from 34 patients receiving 4--7 doses has been analysed. Peripheral neuropathy is related to the total tissue exposure. By monitoring serum levels and controlling the total dose given, convulsions are avoidable and peripheral neuropathy restricted to a low and acceptable level.
3
Clinical testing of the radiosensitizer Ro 07-0582: Experience with multiple doses
Stanley Dische, Megan I. Saunders, M E Lee et al. · British Journal of Cancer · 1977 · 259 citations