Studies on Tenuazonic Acid Analogs. III. Syntheses and Antitumor Activities of Derivatives of Tetramic Acid, Tetronic Acid and Thiotetronic Acid, and Others

Abstract

The ring structure of tenuazonic acid, which is an antitumor antibiotic, was modified to oxazolidine, thiazolidine, and pyrazo1idine ring, in addition to indan-dione derivatives. Their acetyl groups were condensed with a variety of aniline derivatives. The antitumor activity of these modified compounds was examined against Ehrlich solid tumor. None of the compounds tested has shown better effect than Mitomycin-C.