Epitope mapping : a practical approach

Olwyn M.R. Westwood, Frank C. Hay

2000 · 27 citations · 0 references

Concepts

Abstract

Introduction to epitope mapping Synthetic peptides I pepscan assay to define antigenic determinants for antibodies (B cell Epitopes) Delineation of helper T cell epitopes and MHC Combined T and B cell epitopes Cytotoxic T cell eptitopes Peptide mimic libraries Steric competition mapping Oligosaccharide libraries Phage display libraries Site-directed mutagenesis