PubMed · 1990 · 174 citations · 0 references
Tumor InnervationGrowth ControlCell CultureCell ProliferationGliomaCellular PhysiologyDifferentiated PhenotypeNeuro-oncologyNeurogenesisStem CellsHealth SciencesProto-oncogene ExpressionNeuroblastsPharmacologyCell BiologyHuman CellDevelopmental BiologyStem Cell ResearchNeuroscienceHuman Neuroblastoma CellsMedicineNeuronal Cell DifferentiationNeural Stem Cell
The human neuroblastoma cell line, SH-SY5Y, differentiates into neuron-like cells according to morphological, biochemical and functional criteria when treated with biologically active phorbol-esters. The differentiated phenotype is described and alterations in proto-oncogene expression in connection with growth control and differentiation are presented and discussed.