Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Harry Towbin, T. Staehelin, J. Gordon · Proceedings of the National Academy of Sciences · 1979 · 53.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

Haider Raza, Annie John, Abderrahim Nemmar · Cellular Physiology and Biochemistry · 2013 · 47.3K citations · Full text

Life Sciences, Immunology, Toxicology +17

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Jeh-Ping Liu, Julie C. Baker, Archlbald S. Perkins et al. · Cell · 1993 · 2.9K citations

Life Sciences, Developmental Biology, Genetics +16

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

A Ullrich, Jeffrey R. Bell, E. Y. Chen et al. · Nature · 1985 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +12