The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

Engineering, Reverse Genetics, Efficient Site-specific Mutagenesis +14

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Peter Carmeliet, Valérie Ferreira, Georg Breier et al. · Nature · 1996 · 4.1K citations

Developmental Biology, Angiogenesis, Genetics +10

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

Fouad Shalaby, Janet Rossant, Terry P. Yamaguchi et al. · Nature · 1995 · 3.9K citations

Angiogenesis, Blood-island Formation, Immunology +7

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

Lloyd Paul Aiello, Robert L. Avery, Paul G. Arrigg et al. · New England Journal of Medicine · 1994 · 3.8K citations · Full text

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Napoleone Ferrara, Karen Carver-Moore, Helen Chen et al. · Nature · 1996 · 3.6K citations · Full text

Developmental Biology, Vegf Gene, Genetics +10