Effects of candesartan, an angiotensin II type 1 receptor blocker, on diabetic nephropathy in KK/Ta mice - Concepedia

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Effects of candesartan, an angiotensin II type 1 receptor blocker, on diabetic nephropathy in KK/Ta mice

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References

2003

Year

Jie Liao, Michimasa Kobayashi, Yutaka Kanamuru, Shinji Nakamura, Yuichiro Makita, Kazuhiko Funabïki, Satoshi Horikoshi, Yasuhiko Tomino

Journal of Nephrology

Abstract

It appears that candesartan reduced urinary type IV collagen and albumin excretion, and attenuated glomerular hypertrophy and mesangial matrix accumulation by the TGF-betaS/Smad signaling pathway in KK/Ta mice with diabetic nephropathy.