Indian Journal of Pharmaceutical Sciences · 2000 · 12 citations · 0 references
PharmacyPharmaceuticsPharmacologyControlled Release FormulationsDrug DeliveryOral Drug DeliveryDrug Delivery SystemsDrug Release From Dosage FormsDrug Release KineticsNasal FormulationsOphthalmic Formulation DesignOphthalmic FormulationsIn Vivo StudiesPharmacokinetic ParametersPharmacokinetics Of Polymer CarriersRelease Profile CharacterizationZero-order Drug ReleaseZero-order Release Design
Ketorolac tromethamine ocuserts were prepared using different polymers such as HPMC, PVP, MC and EC at various concentrations. The in vitro release of the drug from the formulations was studied using commercial semi permeable membrane. The physico chemical parameters of ocuserts were evaluated. A zero order release formulation 3 (Drug reservoir with 3% HPMC and 4% EC as rate controlling membrane) was subjected to in vivo studies. The expected zero order release for one day was observed in formulation 3 (Drug reservoir with 4% HPMC and 3% EC as rate controlling membrane).