PubMed · 2000 · 18 citations · 10 references
PharmacyBiomedical InformaticsHealth InformaticsClinical InformaticsEarly DetectionElectronic Health RecordsAdverse Drug Event DetectionAdverse Drug Event ReportingAdverse Drug Reaction ReportingAdverse Event ReportingDrug Safety InformaticsDrug Safety MonitoringAdverse Drug EventsAdverse Drug Reaction Reporting SystemsData Dictionary DevelopmentData Dictionary ManagementDrug Safety SurveillanceMedication Safety Reporting SystemsProbability AssessmentRisk Probability Assessment
BACKGROUND: Adverse events are a leading cause of morbidity and mortality. Adverse Drug Events (ADEs) are frequent, under-reported, costly, and largely preventable. Computerized tools expose effectively ADEs and can reduce their impact. METHODS: RADARx is a Veterans Administration (VA) VistA-compatible M software program that integrates computerized ADE screening, probability assessment, documentation, and reporting capabilities. Data dictionary mapping tools have enabled RADARx implementation at 3 sites. All RADARx alerts generated at VA Medical Center (VAMC) Nashville from 7/1/99 to 9/30/99 were evaluated. RESULTS: Total ADEs documented using RADARx numbered 57. RADARx discovered 34 ADEs and 48 'potential' ADEs; 23 ADEs were found using traditional means. Overall, 11% of RADARx alerts were true positives. Pharmacist review of the 8-20 alerts generated daily costs between 10 and 30 minutes.
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A method for estimating the probability of adverse drug reactions
C. A. Naranjo, U. Busto, Edward M. Sellers et al. · Clinical Pharmacology & Therapeutics · 1981 · 11.6K citations
Ashish K. Jha, Gilad J. Kuperman, Jonathan M. Teich et al. · Journal of the American Medical Informatics Association · 1998 · 517 citations · Full text