Antidotal effectiveness of N-acetylcysteine in reversing acetaminophen-induced hepatotoxicity

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

Owen W. Griffith · Analytical Biochemistry · 1980 · 4.6K citations

Life Sciences, Biochemistry, Redox Biochemistry +6

ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. II. ROLE OF COVALENT BINDING IN VIVO

David J. Jollow, John R. Mitchell, William Z. Potter et al. · Journal of Pharmacology and Experimental Therapeutics · 1973 · 1.2K citations

Veterinary Medicine, Pharmacology, Toxicology +17

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

Per O. Seglen, Bjørn Grinde, Anne E. Solheim · European Journal of Biochemistry · 1979 · 470 citations · Full text

Life Sciences, Cell Biology, Cellular Metabolism +10

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

Matthew D. Moore, Hjördis Thor, Gregory Moore et al. · Journal of Biological Chemistry · 1985 · 411 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Mechanism of Action of N-Acetylcysteine in the Protection Against the Hepatotoxicity of Acetaminophen in Rats In Vivo

Bernhard H. Lauterburg, George B. Corcoran, Jerry R. Mitchell · Journal of Clinical Investigation · 1983 · 352 citations · Full text

Pharmacy, Pharmacology, Toxicology +16