Development of dissolution medium for a poorly water soluble drug, celecoxib

Abstract

Celecoxib, a non-steroidal antiinflammatory drug is poorly water soluble. In the present study a new dissolution medium was developed, as there is no official dissolution medium. The composition of the medium was selected on the basis of solubility data of celecoxib at 37Âo. Solubility data revealed that water consisting of 2% w/v sodium lauryl sulphate could be a suitable dissolution medium. The discriminating power of the selected dissolution medium (2% w/v sodium lauryl sulphate in water) relative to other dissolution mediums was evaluated and the results further justified the usage of 2% w/v sodium lauryl sulphate in water as dissolution medium for celecoxib.