Daily monitoring of biomarkers of sepsis in complicated long-term ICU-patients: can it support treatment decisions?

Abstract

PCT > 0.43 ng/mL could add to the clinical propensity for sepsis vs. SIRS not related to infection. Values higher than 1.58 ng/mL may support the bedside clinical diagnosis of severe-sepsis. PCT between 0.5 and 1.0 suggest tight daily monitoring of clinical conditions and re-evaluation of PCT.

References

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	Year	Citations
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure Jean‐Louis Vincent, Rui P. Moreno, Jukka Takala, Intensive Care Medicine Viral SepsisAcute CareSepsisSepsis PhenotypingOrgan Dysfunction/failure	1996	11.2K
A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study J. R. Le Gall JAMA	1993	6.3K
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 R. Phillip Dellinger, Mitchell M. Levy, Jean Carlet, Intensive Care Medicine Critical Care ManagementTrauma ResuscitationSevere SepsisAcute CarePatient Safety	2007	4.9K
Procalcitonin increase after endotoxin injection in normal subjects. Paresh Dandona, David E. Nix, Michael F. Wilson, The Journal of Clinical Endocrinology & Metabolism InflammationTranslational MedicineAntimicrobial SusceptibilityDisease PathophysiologyProcalcitonin Concentration	1994	919
Comparison of procalcitonin and C-reactive protein as markers of sepsis Aldo Luzzani, Enrico Polati, Romolo M. Dorizzi, Critical Care Medicine	2003	429
Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction Gian Paolo Castelli, Claudio Pognani, Michael Meisner, Critical Care	2004	408
Procalcitonin increase in early identification of critically ill patients at high risk of mortality* Jens‐Ulrik Stæhr Jensen, Lars Heslet, Tom Hartvig Jensen, Critical Care Medicine	2006	380
Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS Michael Meisner, Klaus Tschaikowsky, Thomas Palmaers, Critical Care	1999	328
Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients Michael Meisner, Heide Adina, Joachim Schmidt Critical Care	2005	228
Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children C Rey, Marta Los Arcos, Andrés Concha, Intensive Care Medicine InflammationIll ChildrenAutoimmune DiseaseAcute CareImmunology	2007	162

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