PubMed · 1993 · 14 citations · 0 references
Veterinary MedicineInfectious DiseasesPathologyHepatologyImmunopathologyInflammationImmunodeficiency DisordersImmunopathology Of Parasitic DiseaseLiver Blood FlowLiver DiseaseMacrophage Responses To ParasitesParasitic PathologyAcquired Immunodeficiency SyndromeBlood FlowHiv-associated ImmunosuppressionImmunopathology Of LeishmaniasisLeishmaniasis PathogenesisLeishmaniasis PathologySinusoidal Blood FlowVisceral Leishmaniasis
We present a patient with human immunodeficiency virus (HIV) infection coincident with diffuse nodular regenerative hyperplasia (DNRH) of the liver and visceral leishmaniasis. This association has not been previously described. Some DNRH cases are secondary to irregular blood flow in the liver. In the presently described case, there exist two possible conditioning factors for heterogeneous distribution of blood flow: 1) the increased blood flow from splenomegaly, and 2) the irregular circulation of blood through sinusoids infiltrated by Leishmania-parasitized hyperplastic macrophages.