Concepedia

Experimental research A novel ropivacaine-loaded in situ forming implant prolongs the effect of local analgesia in rats

Lei Lü, Wei Zhang, Xin Wu, Xiaoyu Wang, Min Zhang, Quangang Zhu, Xueying Ding, Zhi-yun Xu, Shen Gao, Jing Gao

Archives of Medical Science · 2012 · 13 citations · 24 references

DOIFull text

Open access

Abstract

The biodegradable Ropi-HCl-loaded ISI system with NMP-BB may prove to be an attractive and safe alternative for the delivery of parenteral local anesthetics to prolong pain relief.

References

24

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Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers

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COMPARISON OF EXTRADURAL ROPIVACAINE AND BUPIVACAINE

Michael Brockway, J. Bannister, J. H. McClure et al. · British Journal of Anaesthesia · 1991 · 232 citations · Full text

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Phase inversion dynamics of PLGA solutions related to drug delivery

Paul Graham, K.J. Brodbeck, A. J. McHugh · Journal of Controlled Release · 1999 · 213 citations

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Lidocaine-loaded biodegradable nanospheres. I. Optimization of the drug incorporation into the polymer matrix

T Görner · Journal of Controlled Release · 1999 · 211 citations

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