Concepedia

Chitosan-Based Intelligent Microneedles for Delivery of Amphotericin B Loaded Oleosomes: Antifungal Ocular Patch Targeting for Effective Against Fungal Keratitis Using Rabbit Model via TLR4/NLRP3 Pathway

Sammar Fathy Elhabal, Saeed A. S. Al-Zuhairy, Mohamed Fathi Mohamed Elrefai, Mohamed A. El-Nabarawi, Sandra Hababeh, Kristina Zarif Attalla, Mai S. Shoela, Jakline Nelson, Marwa Fady, Nahla A. Elzohairy,

International Journal of Nanomedicine · 2025 · 17 citations · 47 references

DOIFull text

Open access

Abstract

The AmB-Ole/MNs system as an innovative ocular delivery platform for fungal keratitis offers sustained drug release, enhanced permeation, potent antifungal activity, and reduced toxicity. AmB-Ole/MNs showed promise for ocular AmB delivery for FK.

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