Versatile Solid-State Medical Superglue Precursors of α-Lipoic Acid

Abstract

α-Lipoic acid ( αLA ) is an attractive building block for medical adhesives. However, due to poor water solubility of αLA and high hydrophobicity of poly(αLA), elevated temperatures, organic solvents, or complex preparations are typically required to obtain and deliver αLA -based adhesives to biological tissue. Here, we report αLA -based powder and low-viscosity liquid superglues that polymerize and bond rapidly upon contact with wet tissue. A monomeric mixture of αLA, sodium lipoate, and an activated ester of lipoic acid was used to formulate the versatile adhesives. Stress–strain measurements of the wet adhesives confirmed the high flexibility of the adhesive. Moreover, a small molecule regenerative drug was successfully incorporated into and released from the adhesive without altering the physical and adhesive properties. In vitro and in vivo studies of the developed adhesives confirmed their cell and tissue compatibility, biodegradability, and potential for sustained drug delivery. Moreover, due to the inherent ionic nature of the adhesives, they demonstrated high electric conductivity and sensitivity to deformation, allowing for the development of a tissue-adherent strain sensor.