A Mn–Rh dual single-atom catalyst for inducing C–C cleavage: relay catalysis reversing chemoselectivity in C–H oxidation

Abstract

@O-TiC) and this DSAC demonstrates remarkable selectivity and conversion efficiency in the oxidation reaction of cumene, facilitating the highly efficient production of acetophenone (AP) in an almost quantitative form. The two completely isolated metal catalytic centers, Mn and Rh, each playing a distinct role in the reaction, synergistically propel the directed conversion of cumene to AP in a well-defined manner. This investigation not only illustrates a rare instance of dual single-atom catalyst-mediated relay catalysis in organic synthesis but also imparts valuable insights into the systematic design of catalytic systems for organic tandem reactions, approached from the vantage point in the atomic scale.