Concepedia

Drugless peptide-based nanohybrids alleviate diabetic retinopathy by suppressing microglial activation and endothelial inflammation

Mei Du, Xiao Zhao, Miao Guo, Xiaoyu Wang, Yutian Zhang, Linshan Yang, Sixia Liu, Liya Sun, Mengyu Liao, Dong Xue,

Theranostics · 2025 · 11 citations · 0 references

Open access

Concepts

PharmacyOphthalmologyPharmaceuticsDrug DeliveryInflammationNanoparticle Drug DeliveryDiabetic RetinopathyNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanomedicineNanoparticle DesignOcular NanocarriersAnti-inflammatory NanomaterialsDiabetic Retinopathy ImmunologyDiabetic Retinopathy TherapyMicroglial Activation Gene ExpressionNanomaterials For Ocular ApplicationsPeptide NanoparticlesPeptide-based Biomaterials

Abstract

Our findings suggest that local injection of properly designed, drugless, peptide-based nanohybrids can serve as a safe and effective anti-inflammatory nanomedicine for treating DR.