Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in <i>Neisseria gonorrhoeae</i> and Colonization With Tetracycline-Resistant <i>Staphylococcus aureus</i> and Group A <i>Streptococcus</i>

Abstract

TetR in NG rapidly increased from 2021 to 2024, and most NG among King County MSM now have HL tetR. Doxy PEP use is associated with colonization with GAS and tetracycline-resistant S. aureus, suggesting that doxy PEP impacts off-target bacteria.