PubMed · 2010 · 2.7K citations · 0 references
PharmacyPharmaceuticsPharmacokineticsDrug DeliveryOral Drug DeliveryPharmacokinetic ModelingDrug Delivery SystemsDrug DissolutionDrug DistributionDrug Release From Dosage FormsDrug Release KineticsKinetic ModelingDissolution Rate AnalysisDissolution-mediated Drug ReleaseDrug Dissolution KineticsDrug Release MechanismsDrug Release ModelingKorsmeyer-peppas ModelMechanistic Kinetic ModelingTherapeutic Device Design
In this paper we review the mathematical models used to determine the kinetics of drug release from drug delivery systems. The quantitative analysis of the values obtained in dissolution/release rates is easier when mathematical formulae are used to describe the process. The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.