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Kinetic modeling on drug release from controlled drug delivery systems.
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2010
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Drug AnalysisEngineeringPharmacokinetic ModelingDissolution/release RatesMedicineRelease MechanismPharmaceutical TechnologyDrug Delivery SystemsDrug ReleaseBiomedical EngineeringDrug AbsorptionDrug Delivery SystemPharmacologyChemical KineticsDelivery SystemMathematical ModelsDrug DiscoveryQuantitative Pharmacology
In this paper we review the mathematical models used to determine the kinetics of drug release from drug delivery systems. The quantitative analysis of the values obtained in dissolution/release rates is easier when mathematical formulae are used to describe the process. The mathematical modeling can ultimately help to optimize the design of a therapeutic device to yield information on the efficacy of various release models.