Journal of the American Veterinary Medical Association · 1980 · 14 citations · 0 references
MedicineHematologyPathologyHematopathologyHemostasisTransfusion MedicineBleeding DisordersCoagulation AbnormalitiesCoagulation DisordersCoagulation Factor DeficienciesHemostatic DisordersVon Willebrand DiseaseBleedingBleeding Time AssessmentFactor Viii ActivationVon Willebrand Disease DiagnosisVon Willebrand Factor Activity AssaysVon Willebrand Factor AntigenVon Willebrand Factor DisordersVon Willebrand Factor Function
SUMMARY A bleeding disease similar to von Willebrand's disease in man was diagnosed in a 6-month-old Chesapeake Bay Retriever with recurrent, protracted gingival hemorrhage that responded rapidly to fresh, whole blood transfusions. The dog had a prolonged bleeding time and low plasma factor VIII coagulant activity (18%). The plasma had no detectable factor VIII-related antigen or von Willebrand factor, as measured by ristocetin-cofactor and polybrene-cofactor activities. The dam of the dog had a plasma factor VIII-related antigen concentration (32%) well below the normal range. The antigen in the sire's plasma was at the low end of the normal range, as was the polybrene-cofactor of both the sire and the dam. These data suggested an inherited basis for von Willebrand's disease in this dog.