Development of Chitosan-Polyacrylic Acid Complex Systems for Enhanced Oral Delivery of Lactobacillus Gasseri and Bifidobacterium Bifidum Probiotics

Abstract

The CS-PAA complexes demonstrate a promising mechanism for the effective delivery of incorporated probiotics. The probiotics exhibited high viability and maintain stability under physiological conditions, and showed a remarkable anti-biofilm activity. These characteristics suggest that CS-PAA could serve as an alternative system for probiotics, enhancing gut microbiota health and offering a robust protection against microbial pathogens.