Industrial & Engineering Chemistry Research · 2025 · 47 citations · 53 references
EngineeringChemical EngineeringChemistryIndustrial ChemistryInorganic ChemistryReaction EngineeringCatalytic Reaction EngineeringIndustrial Catalytic ProcessesProcess SynthesisProduction OptimizationReaction Process DesignReactor DesignCatalytic Process OptimizationMesoporous MaterialsPilot-scale ReactorsProduction Cost AnalysisProduction Cost ModelingReaction Process OptimizationSustainable SynthesisSynthetic Route Optimization
Understanding the impact of MOF synthesis conditions on the production cost is vital in order to have a competitive product with a view toward industrial applications. Here, considering the benchmark mesoporous iron(III) trimesate MIL-100(Fe) as a prototypical example, we show that the production cost can reach <30 $/kg if a careful selection of the synthetic route is made. Two routes were considered in the analysis, using sulfate and nitrate as iron sources. A new optimized synthesis protocol in a 5 L laboratory pilot-scale reactor based on iron sulfate was developed using optimized sustainable aqueous ambient pressure conditions, leading to larger particles and a higher space-time yield. Based on reliable pilot-scale data and established chemical engineering estimation methods, this leads to a significantly lower production cost of high-quality MIL-100(Fe), achieving a potential competitive product.
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CHEM21 selection guide of classical- and less classical-solvents
Denis Prat, A.S. Wells, John Hayler et al. · Green Chemistry · 2015 · 2.1K citations · Full text