Antagonism of δ2-Opioid Receptors by Naltrindole-5′-isothiocyanate Attenuates Heroin Self-Administration but Not Antinociception in Rats

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Medicine, Neuroscience, Pharmacology +17

Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats

James R. Weeks · Science · 1962 · 657 citations

Medicine, Neurology, Psychiatry +7

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

Philip S. Portoghese, Marjia Sultana, A.E. Takemori · European Journal of Pharmacology · 1988 · 613 citations

Medicine, Medicinal Chemistry, Pharmacology +10

The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study

Rainer Spanagel, Albert Herz, Toni S. Shippenberg · Journal of Neurochemistry · 1990 · 541 citations

Medicine, Neuroscience, Pharmacology +17

Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

Essam E. Abdelhamid, Marjia Sultana, Philip S. Portoghese et al. · Journal of Pharmacology and Experimental Therapeutics · 1991 · 427 citations

Medicine, Pharmacology, Neuropharmacology +16