GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers - Concepedia

Concepedia

Publication | Open Access

GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers

DOI Full Paper Access

12

Citations

35

References

2024

Year

Yitong Li, Weiqing Shao, Zhenmei Chen, Xiaochen Ma, Chenhe Yi, Baorui Tao, Bo Zhang, Yue Ma, Guo Zhang, Rui Zhang,

Clinical and Molecular Hepatology

Abstract

In MASH livers, upregulation of GOLM1 by IL-1β increases ABCG5-mediated cholesterol efflux in an OPN-dependent manner, promoting CGS formation. GOLM1 has the potential to be a molecular hub interconnecting MASH and CGSs.

References

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