Xylazine induces dopamine release and augments the effects of fentanyl

Xylazine — Medical and Public Health Imperatives

Rahul Gupta, David R. Holtgräve, Michael A. Ashburn · New England Journal of Medicine · 2023 · 155 citations · Full text

Medicine, Pharmacology, Clinical Pharmacology +1

<i>Notes from the Field</i>: Xylazine, a Veterinary Tranquilizer, Identified as an Emerging Novel Substance in Drug Overdose Deaths — Connecticut, 2019–2020

Shobha Thangada, Heather A. Clinton, Sarah Ali et al. · MMWR Morbidity and Mortality Weekly Report · 2021 · 56 citations · Full text

Pharmacy, Pharmacology, Toxicology +11

Noradrenergic Modulation of Dopamine Transmission Evoked by Electrical Stimulation of the Locus Coeruleus in the Rat Brain

Jin W. Park, Jinwoo Park, Jinwoo Park · ACS Chemical Neuroscience · 2017 · 44 citations

Life Sciences, Neurobiology, Neuroscience +17

Xylazine suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome that is not altered by naloxone in rats.

Shailesh Khatri, Safiyah Sadek, Percell Kendrick et al. · Experimental and Clinical Psychopharmacology · 2023 · 41 citations · Full text

Medicine, Pharmacology, Behavioral Pharmacology +9

Here’s What to Know About Xylazine, aka Tranq, the Animal Tranquilizer Increasingly Found in Illicit Fentanyl Samples

Rita Rubin · JAMA · 2023 · 26 citations

Pharmacy, Pharmacology, Toxicology +5