Epitranscriptomic regulation of cardiac fibrosis via YTHDF1-dependent <i>PIEZO2</i> mRNA m6A modification

Abstract

We demonstrated a novel epitranscriptomic mechanism through which YTHDF1 recognizes Piezo2 and controls cardiac fibroblast autophagy and fibrosis through m6A-dependent modulation. Our findings provide new insights for the development of preventive measures for cardiac fibrosis.