Longitudinal <scp>Magnetic Resonance Imaging</scp> in Asymptomatic <i>C9orf72</i> Mutation Carriers Distinguishes Phenoconverters to <scp>Amyotrophic Lateral Sclerosis or Amyotrophic Lateral Sclerosis With Frontotemporal Dementia</scp>

Abstract

Distinctive atrophy patterns are visible years before symptom onset on presymptomatic scans of phenoconverters. Combining baseline and follow-up similarity measures may serve as a promising imaging biomarker for identifying those at risk of ALS or ALS-FTD. ANN NEUROL 2025;97:281-295.