Theranostics · 2024 · 81 citations · 0 references
Life SciencesNeurosciencePharmacologyDementiaNeurodegenerationRedox BiochemistryAlzheimer DiseaseAntioxidant DefenseNeurodegeneration MechanismsNeurodegenerative DiseasesNeurodegenerative DisordersNeuroprotectionAlzheimer Disease NeuroprotectionCellular Redox BalanceCellular Redox SignalingGlutathione Peroxidase 4Glutathione Peroxidase ActivityGlutathione Peroxidase InhibitionRedox EquilibriumRedox Metabolism In Neurodegeneration
ThA ameliorates AD by inhibiting neuronal ferroptosis mediated by GPX4 activation through its binding with GPX4 and the upregulation of the AMPK/Nrf2/GPX4 pathway.